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Research insights and technical articles from GeneMedi.
A study published in Nature Medicine followed 38 patients with B-cell non-Hodgkin lymphoma treated with 4-1BB-costimulated CD19 CAR-T for up to ten years. The results showed that C...
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A preclinical study published in Science Translational Medicine used split intein protein trans-splicing and a muscle-tropic AAV vector to reconstruct full-length dysferlin in an L...
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A 3-year-old child with infantile Krabbe disease developed a GLI1-altered tumor paravertebral to L2–L3 after receiving AAV gene therapy. Long-read sequencing showed that a subgenom...
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In autoimmune research, regulatory T cells (Tregs) are generally regarded as the "brakes" that suppress excessive immune responses. However, a mouse study published in the Journal ...
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Research Background Severe inflammatory lung disease, including acute respiratory distress syndrome (ARDS), has a high mortality rate and limited targeted therapeutic options. Rece...
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In the randomized phase II ImmunoPRISM trial, patients with high-risk smoldering multiple myeloma received a fixed course of the BCMA×CD3 bispecific antibody teclistamab, achieving...
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A phase 2 randomized trial shows that in people who started antiviral treatment early, two long-acting broadly neutralizing antibodies can delay viral rebound during an analytical ...
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Tumor immunotherapy does not always work, and one often-overlooked reason lies at the starting point of the immune response. Dendritic cells (DCs) are responsible for presenting tu...
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After infection and vaccination, whether the body can produce highly effective antibodies depends on whether B cells can "capture" antigens and present them to T cells. This proces...
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The onset of autoimmune diseases arises from the immune system mistakenly attacking the body's own tissues. Regulatory T cells (Tregs) are the core cell population that maintains i...
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